{"id":1339,"date":"2014-09-02T17:02:04","date_gmt":"2014-09-02T16:02:04","guid":{"rendered":"http:\/\/saber-benmimoun.fr\/?p=1339"},"modified":"2020-11-12T19:03:05","modified_gmt":"2020-11-12T18:03:05","slug":"immortalized-vs-transformed-cells","status":"publish","type":"post","link":"http:\/\/saber-benmimoun.com\/?p=1339","title":{"rendered":"Immortalized Vs Transformed cells"},"content":{"rendered":"<p><span style=\"color: #000000;\">In vitro,\u00a0normal cells taken directly from an animal (referred to as primary cells) can only divide a certain number of times (cells will either enter a senescence\u00a0stage, or die).<\/span><\/p>\n<p><span style=\"color: #000000;\">Transformed cells are cancerous cells. They\u00a0possess all six hallmarks of cancerous cells :\u00a0<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">1- Growth factor independency<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">2- No response to growth inhibitors<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">3- Evasion of apoptosis<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">4- Can promote angiogenesis<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">5- Unlimited proliferation<\/span><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">6- Invasive<\/span><br style=\"color: #000000;\" \/><br style=\"color: #000000;\" \/><span style=\"color: #000000;\">Immortalized cells have sufficient mutations to be able to divide indefinitely in culture. However, they are not cancerous seen their dependence of growth factors and their sensitivity to growth inhibitors. Cells can be immortalized spontaneously or established in the lab (by using\u00a0adenovirus for example).<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In vitro,\u00a0normal cells taken directly from an animal (referred to as primary cells) can only divide a certain number of times (cells will either enter a senescence\u00a0stage, or die). Transformed cells are cancerous cells. They\u00a0possess all six hallmarks of cancerous cells :\u00a01- Growth factor independency2- No response to growth inhibitors3- Evasion of apoptosis4- Can promote&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[],"class_list":["post-1339","post","type-post","status-publish","format-standard","hentry","category-biologie","category-7","description-off"],"_links":{"self":[{"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/posts\/1339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1339"}],"version-history":[{"count":3,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/posts\/1339\/revisions"}],"predecessor-version":[{"id":1342,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=\/wp\/v2\/posts\/1339\/revisions\/1342"}],"wp:attachment":[{"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1339"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/saber-benmimoun.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}